Advances in the construction of a scaffold for cardiac tissue engineering containing homogeneous and stable carbon nanotubes
10.3969/j.issn.2095-4344.0719
- VernacularTitle:构建含有均一、稳定分散碳纳米管心肌组织工程支架的最新进展
- Author:
Dian CHEN
1
;
Qing-Lin HU
;
Mei-Ling ZHOU
;
Xian HONG
;
Xiao-Xi SUN
;
Jiao-Ya XI
Author Information
1. 华中科技大学同济医学院基础医学院生理学系
- From:
Chinese Journal of Tissue Engineering Research
2018;22(10):1580-1585
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: How to efficiently and uniformly disperse carbon nanotubes (CNTs) into a tissue-engineered scaffold is crucial to construct an ideal CNTs-Polymer composite scaffold and it is also a hotspot of research in the tissue engineering. OBJECTIVE: To review the advances in the methodology progress of constructing a scaffold for cardiac tissue engineering, which contains uniformly and stably dispersed CNTs. METHODS: The Web of Science Core Collection and PubMed were searched by the first author for related papers about CNTs dispersion in the cardiac tissue engineering published from October 2004 to January 2017. The key words were "carbon nanotubes, dispersion, cardiac tissue engineering" in English. Original research papers were searched, which were screened through titles, abstracts and contents, and then reviewed. RESULTS AND CONCLUSION: CNTs are easy to aggregate because of high surface area, high aspect ratio and rough surface. Thus, it is one of the key points to construct an ideal CNTs-Polymer composite scaffold that whether CNTs could be uniformly and stably dispersed in polymer scaffolds. In the cardiac tissue engineering, covalent or non-covalent surface modification of CNTs significantly enhances the uniformity and stability of CNTs in the polymer scaffolds, which is conducive to construct the uniformly and stably CNTs-dispersed scaffold for cardiac tissue engineering, leading to notable improvement in mechanical and electrical properties of engineered cardiac tissues.
