Role of macrophage polarization in periprosthetic osteolysis: its research status and advance
10.3969/j.issn.2095-4344.0127
- VernacularTitle:巨噬细胞极化在假体周围骨溶解中的作用:研究现状和进展
- Author:
Dong GONG
1
;
Ping ZHEN
;
Rong WANG
Author Information
1. 解放军兰州军区兰州总医院骨科
- From:
Chinese Journal of Tissue Engineering Research
2018;22(7):1120-1125
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: In terms of both phenotype and function, macrophages have remarkable heterogeneity. In respond to various environmental cues or under different pathophysiologic conditions, macrophages can be polarized into different phenotypes, that is, pro-inflammatory M1 phenotypes (classical activated marcrophage) or anti-inflammatory M2 phenotypes (alternative activated marcrophage). Macrophage polarizatinton has been found to play an important role in periprosthetic osteolysis. OBJECTIVE: To summarize the research status and new progress of the concept of macrophage polarization, the relationship between osteolysis as well as treatment methods of osteolysis. METHODS: A computer-based online retrieval was performed for the literature concerning macrophage polarization and periprosthetic osteolysis in PubMed and CNKI databases published from January 1999 to March 2017. Unrelated researches on macrophage polarization were excluded. The keywords were "macrophage polarization, wear particles, and osteolysis" in English and Chinese, respectively. RESULTS AND CONCLUSION: (1) The periprosthetic osteolysis after artifical joint replacement has a close relationship with macrophage, but few studies have been carried out from the respect of macrophage polarization.Most of researches are still on in vitro observation or experimental stage. (2) Current researches mainly show that macrophages can be polarized into different phenotypes by stimulation of wear particles and cytokines, the peri-implant macrophage phenotype has M1 characteristics and some cytokines can induce macrophages polarization to M2 type with anti-inflammatory characteristics. This conclusion has a broad prospect, but the related mechanisms still remain unclear, which need a further exploration.
