Stem cell-derived exosomes in regenerative medicine: research progress and aplications
10.3969/j.issn.2095-4344.0454
- VernacularTitle:干细胞源外泌体应用于再生医学的研究进展
- Author:
En-Guo ZHANG
1
;
Shang-Ya CHEN
;
Ye YANG
;
Zhong-Jun DU
;
Hua SHAO
Author Information
1. 济南大学 山东省医学科学院医学与生命科学学院
- From:
Chinese Journal of Tissue Engineering Research
2018;22(5):801-806
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: As an emerging cell therapy, stem cell therapy has gradually attracted the attention of researchers in the field of medicine. The mechanisms of stem cell therapy mainly include differentiation and paracrine mechanisms. In recent years, with the further research, people gradually put attention to paracrine mechanisms, especially after the discovery of the great protective potential of stem cell-derived exosomes which can provide a powerful repair tool for the "acellular" treatment of regenerative medicine. OBJECTIVE: To review the repair, protection and possible biological mechanisms of stem cell-derived exosomes in various disease damage models. METHODS: The literature search was performed in PubMed, CNKI and WanFang databases, and the keywords were "stem cell-derived exosomes, exosome, regenerative medicine" in English and Chinese, respectively. According to the inclusion and exclusion criteria, 41 articles were finally reviewed. RESULTS AND CONCLUSION: Stem cell-derived exosomes show outstanding ability to repair and protect many diseases, such as cardiovascular system, traumatic brain injury, musculoskeletal system, liver damage, renal injury, and so on. Although most studies have yet to report their detailed molecular mechanisms of action, stem cell-derived exosomes are expected to become a new "acellular" approach for the repair and protection of organism damage.
