Stem cell repair of intrauterine adhesions: preliminary achievements and clinical translation
10.3969/j.issn.2095-4344.0452
- VernacularTitle:干细胞修复宫腔粘连:初级阶段研究成果的转化意义
- Author:
Xin-Lu ZHAN
1
;
Meng-Ni ZHOU
;
Bu-Zhen TAN
Author Information
1. 南昌大学第二附属医院妇产科
- From:
Chinese Journal of Tissue Engineering Research
2018;22(5):787-792
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Stem cells exhibit immeasurable application potentials in tissue and organ repair, but stem cell transplantation for the treatment of intrauterine adhesions is still in the initial stage. OBJECTIVE: To review the research progress in the stem cell repair of intrauterine adhesions. METHODS: We retrieved ISI Web of Science database, PubMed database and CNKI database for representative clinical research, basic research and reviews concerning stem cell therapy for intrauterine adhesions. The keywords were "intrauterine adhesion, metrosynizesis, Asherman's syndrome, stem cell, endometrial stem cell, stem cell transplantation" in English and Chinese, respectively. After repetitive studies were excluded, 43 articles were reviewed in the result analysis. RESULTS AND CONCLUSION: Hysteroscopic transcervical resection of adhesions is an ideal treatment for intrauterine adhesions, but the postoperative recurrence rate of intrauterine adhesions is still high. The human endometrium has high proliferative activity, and the endometrium of a woman of childbearing age may experience growth, differentiation and exfoliation for over 400 times, indicating the existence of endometrial stem cells.Endometrial stem cells have been isolated from the endometrium,successfully cultured in vitro and induced for directional differentiation. However, studies on endometrial stem cell transplantation for intrauterine adhesions are still in its infancy. Basic research on stem cells will facilitate its application to clinical practice.
