Strategies for promoting the differentiation of cardiac stem cells into cardiomyocytes
10.3969/j.issn.2095-4344.0450
- VernacularTitle:促进心肌干细胞向心肌细胞分化的策略
- Author:
Lei WANG
1
;
Xu-Xiang CHEN
;
Quan-Hua WU
;
Hao WU
;
Hui-Bao LONG
;
Jing-Ying HOU
;
Tong WANG
Author Information
1. 中山大学孙逸仙纪念医院急诊科
- From:
Chinese Journal of Tissue Engineering Research
2018;22(5):774-780
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: In recent years, it has shown that there exist some endogenous cardiac stem cells in the heart. What has been confirmed is that this kind of cells can differentiate into cardiomyocytes to repair the damaged myocardium and improve the cardiac function. OBJECTIVE: To review the current methods of promoting the differentiation of cardiac stem cells into cardiomyocytes. METHODS: PubMed database was searched by computer for articles addressing the differentiation of cardiac stem cells in the last 10 years, using the keywords of "cardiac stem cells, cardiac progenitor cells, differentiation". Finally, 64 English articles were included in result analysis. RESULTS AND CONCLUSION:Recent studies have shown that the differentiation efficiency of cardiac stem cells can be promoted in vivo by introducing cytokines,micro-RNA,and some physicochemical methods,which consequently enhances the therapeutic efficacy of cardiac stem cell transplantation for myocardial infarction.
