Role of stromal cell-derived factor 1/CXC chemokine receptor axis in rat tooth movement
10.3969/j.issn.2095-4344.2017.36.004
- VernacularTitle:基质细胞衍生因子1/CXC族细胞因子受体4信号轴对大鼠牙齿移动速率的影响
- Author:
Qian CHENG
1
;
Fu-Wei LIN
;
Yi-Jia XIE
;
Yue HUANG
;
Jun WANG
Author Information
1. 西南医科大学附属口腔医院正畸科
- From:
Chinese Journal of Tissue Engineering Research
2017;21(36):5757-5762
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Orthodontic treatment has a long course and referral interval,which is an important difficulty.How to accelerate orthodontic tooth movement is an issue of concern.OBJECTIVE:To testify whether the local injection of AMD3100 (CXCR4 antagonist) can accelerate the tooth movement or not,and to explore the role of stromal cell-derived factor 1/CXC chemokine receptor axis in tooth movement.METHODS:Ninety Sprague-Dawley rats aged 8-10 weeks old were selected and the models of orthodontic tooth movement were established.The model rats were randomized into three groups,and then given the injection of stromal cell-derived factor 1,AMD3100 or PBS.The rats were killed at 1,3,5,7,10 and 14 days to measure the tooth movement distance.RESULTS AND CONCLUSION:The tooth movement distance showed difference among three groups;AMD3100 could facilitate the tooth movement,while stromal cell-derived factor 1 exerted inhibitory effect on the tooth movement.To conclude,stromal cell-derived factor 1/CXC chemokine receptor axis plays an important role in tooth movement.
