The curative effect of Fuzhengxiaojia decoction on precancerous lesions of gastric cancer
10.7652/jdyxb201804029
- VernacularTitle:扶正消瘕方治疗胃癌前病变的临床疗效观察
- Author:
Tao SUN
1
;
De-Shan LIU
;
Yu ZHU
;
Lan ZHOU
;
Chang-Ling LI
;
Shi-Qing YAO
;
Chao WANG
;
Li CHEN
Author Information
1. 山东大学临床医学院
- Keywords:
Fuzhengxiaojia;
precancerous lesion of gastric cancer(PLGC);
Weifuchun tablet;
oxygen free radical;
immunoglobulin
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2018;39(4):597-601,608
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the curative effect of Fuzhengxiaojia decoction on precancerous lesion of gastric cancer (PLGC).Methods We randomly divided 44 patients with PLGC in our hospital into control group (n=22)and treatment group (n=22).The control group was given 4 Weifuchun tablets each time and three times per day and while the treatment group was given one Fuzhengxiaojia decoction of 400 mL besides the medication of the control group.They were treated for two courses,one course lasting for one month.Results Superoxide dismutase (SOD),malondialdehyde (MDA),glutathione peroxidase (GSH-Px),IgG,IgM and IgA in the two groups had no significant differences before treatment (P＞0.05).After treatment,compared with those in the control group,SOD (t=2.144,P=0.044)and GSH-Px (t=2.322,P=0.030)increased,while MDA(t=3.096, P=0.005),IgG(t=2.421,P=0.025),IgM(t=3.377,P=0.003)and IgA (t=2.521,P=0.020)decreased. The main symptom scores in the two groups did not significantly differ before treatment (P＜0.05).After treatment, compared with those in the control group,the scores for main symptoms like reduced food intake (t=3.924,P＜0.001),stomach noise (t=4.161,P＜0.001)and gastric or hypochondriac swelling (t=2.881,P＜0.009) decreased in the treatment group.The rate of effective cases was higher than that in the control group (χ2=4.539, P=0.033).Conclusion The effect of Weifuchun combined with Fuzhengxiaojia prescriptions in treating PLGC is better than Weifuchun alone,which is related to improving redox and immunoglobulin.
