Association of in-stent restenosis with serum Gal-3 and MMP-9 levels
10.7652/jdyxb201804008
- VernacularTitle:半乳糖凝集素-3和基质金属蛋白酶-9与支架内再狭窄的关系
- Author:
Xiao-Ting NIU
1
;
Yang XU
;
Yang ZHENG
;
Xiao-Huan LIU
;
Hong GONG
;
Ya-Jie FAN
;
Chun-Yan ZHANG
;
Yan ZHANG
;
Yan-Chao HU
;
Yong-Qin LI
;
Cong-Xia WANG
Author Information
1. 西安唐城医院心血管内科
- Keywords:
coronary atherosclerotic heart disease;
galectin-3(Gal-3);
matrix metalloproteinase-9(MMP-9);
in-stent restenosis;
major adverse cardiovascular event(MACEs)
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2018;39(4):483-487,503
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of galectin-3 (Gal-3)and matrix metalloproteinase-9 (MMP-9)with in-stent restenosis (ISR).Methods We consecutively recruited 434 patients who had undergone successful drug eluting stent (DES)implantation.Then we divided them into ISR group (n=41)and NO-ISR group (n=393)according to the results of coronary angiography review.Independent risk factors for ISR were found out by multivariate analysis and the two groups were matched for these factors except for Gal-3 and MMP-9 .After elim-ination of the influence of confounders,serum Gal-3 and MMP-9 were compared between the groups and their rela-tions with the severity of ISR were analyzed.Patients were grouped based on Gal-3 and MMP-9 concentrations and major adverse cardiac events (MACEs)were compared between the two groups.Results After elimination of the influence of confounders,the results showed that serum levels of Gal-3 and MMP-9 were significantly higher in ISR group than in NO-ISR group (P＜0.001).Serum levels of Gal-3 and MMP-9 increased with the increased grade of classification.Serum levels of Gal-3 and MMP-9 were obviously higher in classes Ⅲ and Ⅳ ISR than in class Ⅰ (P＜0.05).Patients with higher levels of Gal-3 and MMP-9 had a higher incidence of MACEs (P＜0.01).ISR group had a higher incidence of MACEs than NO-ISR group (P＜0.05).Conclusion Serum levels of Gal-3 and MMP-9 are correlated with ISR and its severity,and they are independent risk factors for ISR.The rate of MACEs during follow-up period was increased with the increased levels of Gal-3 and MMP-9 .
