Correlation between the degree of coronary artery stenosis and endothelial dysfunction in patients with coronary heart disease and subclinical hypothyroidism
10.7652/jdyxb201804005
- VernacularTitle:冠心病合并亚临床甲减患者冠状动脉狭窄程度与内皮功能损伤的相关性
- Author:
Xiao-Hui QUAN
1
;
Cong-Xia WANG
;
Chun-Yan ZHANG
;
Yan ZHANG
;
Xuan GUO
;
Shan JIA
;
Wei-Dong MA
;
Yang ZHENG
;
Hong GONG
;
Tuo HAN
;
Yang XU
Author Information
1. 西安交通大学第二附属医院心血管内科
- Keywords:
coronary heart disease;
subclinical hypothyroidism;
endothelin(ET);
nitric oxide
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2018;39(4):471-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between coronary artery stenosis and endothelial dysfunction in patients with coronary heart disease and subclinical hypothyroidism.Methods According to the results of coronary angiography and thyroid function,the patients were divided into coronary heart disease with subclinical hypothyroidism (group A,n=71),coronary heart disease without subclinical hypothyroidism (group B,n=73), and normal coronary angiography (control group,n=59).The degree of coronary artery stenosis was evaluated by Gensini integral method.Fasting blood was taken to measure nitric oxide (NO),high sensitivity C reactive protein (hs-CRP),and endothelin (ET)to evaluate endothelial dysfunction.Results TC,TG,LDL-c,FT3,TSH,hs-CRP,ET and Gensini score were higher in Group A than in Group B and control group (P＜0.05).The level of NO in Group A and Group B were lower than that in control group (P＜0 .0 5).Multivariate Logistic regression analysis showed that age,TSH,ET and NO were independent risk factors for coronary heart disease.ET and NO levels in patients with coronary heart disease combined with subclinical hypothyroidism were correlated with Gensini scores (r=0.431,r=-0.383,P＜0.001).Conclusion Subclinical hypothyroidism may cause endothelial dysfunction in patients with coronary heart disease,which may increase cardiovascular risk in these patients.
