Predictive values of the platelet to lymphocyte ratio and neutrophil to lymphocyte ratio for drug eluting stent restenosis
10.7652/jdyxb201804004
- VernacularTitle:血小板/淋巴细胞比值和中性粒细胞/淋巴细胞比值对药物洗脱支架内再狭窄的预测价值
- Author:
Yang ZHENG
1
;
Xiao-Huan LIU
;
Wei-Dong MA
;
Shan JIA
;
Ya-Jie FAN
;
Zhi-Hui YAO
;
Chun-Yan ZHANG
;
Yan ZHANG
;
Yan-Chao HU
;
Miao GE
;
Cong-Xia WANG
Author Information
1. 西安交通大学第二附属医院心血管内科
- Keywords:
coronary heart disease;
in-stent restenosis;
platelet to lymphocyte ratio;
neutrophil to lymphocyte ratio;
predictive value
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2018;39(4):466-470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive values of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR)before percutaneous coronary intervention (PCI)and a reexamination of coronary angiography (CAG)on the development of in-stent restenosis (ISR)in patients implanted with coronary drug eluting stent (DES).Methods For this study we enrolled 123 patients who had undergone successful drug eluting stent implantation (SI)and a further CAG reexamination.Another 45 patients with non-coronary heart disease (NC)served as controls.PLR and NLR were measured before DES implantation or CAG and compared between the groups.Patients in SI group were further divided into two subgroups based on the results of CAG reexamination:ISR group and no-ISR group.Hematologic data were reexamined before further CAG and compared between the subgroups.Receiver operator characteristic curve (ROC)was drawn to evaluate the predictive values of PLR and NLR for ISR.Results PLR and NLR before PCI or a further CAG were significantly higher in ISR group (34 patients)than in non-ISR group (89 patients,P＜0.05).Before PCI,the best cutoff value of PLR in screening restenosis was 107.20;the sensitivity and the specificity were 64.7% and 65.2%.The best cutoff value of NLR in screening restenosis was 2.72; the sensitivity and the specificity were 61.8% and 70.8%. Before CAG reexamination,the best cutoff value of PLR in screening restenosis was 160.08;the sensitivity and the specificity were 26.5% and 97.8%.The best cutoff value of NLR in screening restenosis was 2.08;the sensitivity and the specificity were 73.5% and 56.2%.Conclusion Both PLR and NLR before PCI or CAG reexamination can be predictors of ISR in patients implanted with DES.
