Mechanism of diabetic kidney disease and its relationship with cardiovascular disease based on genomics
10.7652/jdyxb201802022
- VernacularTitle:基于基因组学探讨糖尿病肾病的发病原因及其与心血管疾病的关系
- Author:
Xiao-Mei REN
1
;
Jing-Feng YANG
;
Qi-Ling LIU
;
Bao XIN
;
Rong-Qiang ZHANG
Author Information
1. 陕西中医药大学公共卫生学院
- Keywords:
diabetic kidney disease;
cardiovascular disease;
differentially expressed gene;
transcriptional spec-trum
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2018;39(2):266-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide the basis for early diagnosis and clinical treatment for diabetic kidney disease(DKD)and cardiovascular disease by analyzing the causes of DKD and the relationship between them. Methods Microarray gene chip data from the glomerulus in DKD were downloaded from GEO Database.The gene expression profile,gene function,protein-protein interaction network,gene and signal pathway co-expression network of control and DKD groups were analyzed and the key node genes between the two groups were selected by R,QOE,GCBI,STRING and Genclip.Results The gene expression profile of glomerular tissue in DKD patients was significantly altered.Compared with control group,there were 844 differentially expressed genes in DKD patients.One protein-protein interaction network with the core of TNNT 2 occurred among top 20 differentially expressed genes.Differentially expressed genes were mainly related to inflammatory and stress responses,as well as to MAPK signal pathway.Conclusion The cause of DKD is mainly related to inflammatory and stress responses, which are also related to cardiovascular disease.
