Advances in Study on Role of Non-coding RNA in Ulcerative Colitis
10. 3969/j. issn. 1008-7125. 2018. 06. 010
- VernacularTitle:非编码RNA在溃疡性结肠炎中作用的研究进展
- Author:
Tingting WANG
1
;
Weixia REN
;
Fangfang GAO
;
Lei YE
;
Ying HAN
;
Qi ZHANG
;
Yujun ZHANG
Author Information
1. 北京大学人民医院中心实验室 100044
- Keywords:
Colitis,Ulcerative;
RNA,Untranslated;
MicroRNAs;
Long Non-Coding RNA;
Circular RNA
- From:
Chinese Journal of Gastroenterology
2018;23(6):366-369
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis (UC)is a chronic non-specific inflammatory disease involving colon and rectum,and its etiology is not yet fully defined. UC is recurrent and can develop into colorectal cancer. Non-coding RNA (ncRNA)such as microRNA,long non-coding RNA (lncRNA),circular RNA (circRNA)plays a significant role in the process of growth and development of diseases. NcRNA can induce UC via promoting inflammatory cell infiltration,weakening intestinal mucosal barrier function and inducing intestinal epithelial cell apoptosis,and participate in its cancerization. This article reviewed the advances in study on role of ncRNA in UC.
