Effect of Metal Stents Combined With Nasobiliary Drainage on Preventing post-ERCP Cholangitis in Patients With Cholangiocarcinoma
10. 3969/j. issn. 1008-7125. 2018. 06. 007
- VernacularTitle:金属支架置入联合鼻胆管引流对胆管癌患者ERCP术后胆管炎的预防作用
- Author:
Sumin CHEN
1
;
Yingchun REN
;
Qiuyan ZHAO
;
Xinjian WAN
;
Baiwen LI
Author Information
1. 上海交通大学附属第一人民医院消化内科 201620
- Keywords:
Bile Duct Neoplasms;
Endoscopic Metal Biliary Endoprothesis;
Endoscopic Nasobiliary Drainage;
Cholangitis;
Therapy
- From:Chinese Journal of Gastroenterology
2018;23(6):351-355
- CountryChina
- Language:Chinese
-
Abstract:
Background:Cholangitis is common in patients with advanced cholangiocarcinoma after endoscopic metal biliary endoprothesis (EMBE). Aims:To explore the effect of EMBE combined with endoscopic nasobiliary drainage (ENBD)on preventing post-ERCP cholangitis in patients with cholangiocarcinoma. Methods: A total of 263 advanced cholangiocarcinoma patients underwent EMBE were enrolled and divided into EMBE group and EMBE plus ENBD group. Incidence of post-ERCP cholangitis,adverse event rate and hospital stay were evaluated between the two groups. Results:Compared with EMBE group,incidence of post-ERCP cholangitis (2. 3% vs. 10. 8%,P ＝0. 032 )and hospital stay [(4. 68 ± 1. 43)days vs. (5. 18 ± 1. 45 )days,P ＝0. 011 ]were significantly lower in EMBE plus ENBD group, especially in patients with hilar cholangiocarcinoma [incidence of post-ERCP cholangitis:3. 5% vs. 15. 0%,P＝0. 045;hospital stay:(5. 18 ± 1. 44)days vs. (5. 68 ± 1. 39)days,P＝0. 033]. C-reactive protein,white blood cell count, percentage of neutrophil after 3,24,72 hours were significantly decreased in EMBE plus ENBD group than in EMBE group (P＜0. 05). No significant difference in procedure-related adverse event was found between the two groups (P＞0. 05). Conclusions:The combination of EMBE with ENBD is safe and effective in preventing post-ERCP cholangitis,especially in patients with hilar cholangiocarcinoma.
