Advances in Diagnosis and Treatment of Primary Sclerosing Cholangitis
10.3969/j.issn.1008-7125.2018.05.004
- VernacularTitle:原发性硬化性胆管炎诊治进展
- Author:
Guanya GUO
1
;
Yu CHEN
;
Ying HAN
Author Information
1. 空军军医大学西京医院消化病医院 710032
- Keywords:
Primary Sclerosing Cholangitis;
Cholangiography;
Ursodeoxycholic Acid;
Inflammatory Bowel Disease;
Intestinal Microecology;
Prognostic Stratification
- From:
Chinese Journal of Gastroenterology
2018;23(5):271-276
- CountryChina
- Language:Chinese
-
Abstract:
Primary sclerosing cholangitis (PSC)is a chronic cholestatic liver disease characterized by inflammation, fibrosis,and stricture of the intra- and/ or extrahepatic bile ducts. PSC is frequently insidious onset,but may aggravate progressively and ultimately leading to biliary cirrhosis and eventually hepatic failure. Most of the PSC patients are associated with inflammatory bowel disease,and the risk of hepatobiliary malignancy especially cholangiocarcinoma increases significantly. So far,the mechanism of PSC is not clearly known and lacking effective medical therapy. This article provides a comprehensive review on advances in diagnosis and treatment of PSC,including the consensus on imaging diagnosis,prognostic stratification and new drugs in ongoing trials.
