Advances in Study on Role of Cathepsin S in Irritable Bowel Syndrome
10.3969/j.issn.1008-7125.2018.04.012
- VernacularTitle:组织蛋白酶S在肠易激综合征中作用的研究进展
- Author:
Shuangshuang WANG
1
;
Chaoying CHEN
;
Bin L(U)
;
Lu ZHANG
Author Information
1. 浙江中医药大学附属第一医院消化内科 310006
- Keywords:
Cathepsins;
Irritable Bowel Syndrome;
Inflammation;
Antigen;
Therapy
- From:
Chinese Journal of Gastroenterology
2018;23(4):248-250
- CountryChina
- Language:Chinese
-
Abstract:
Irritable bowel syndrome(IBS)is a common functional intestinal disease,and its etiology and pathogenesis are not completely clear. The pathogenesis of IBS involves disturbed gastrointestinal motility,gut hypersensitivity,intestinal inflammation,immune dysfunction and brain-gut axis abnormality. Cathepsin S(CTSS)is a proteolytic enzyme widely distributed in various cell lysosomes,and participates in a variety of pathophysiological processes. Recent studies have shown that CTSS may be involved in the pathogenesis of IBS. This article reviewed the advances in study on role of CTSS in IBS.
