Advances in Study on Statins in Prevention of Colorectal Cancer
10.3969/j.issn.1008-7125.2018.04.011
- VernacularTitle:他汀类药物在结直肠癌预防中作用的研究进展
- Author:
Weifen QIAN
1
;
Pingping XU
;
Zhen HAN
Author Information
1. 皖南医学院第一附属医院 弋矶山医院消化内科 241001
- Keywords:
Statins;
Colorectal Neoplasms;
Adenocarcinoma;
Adenoma;
Chemoprevention
- From:
Chinese Journal of Gastroenterology
2018;23(4):245-247
- CountryChina
- Language:Chinese
-
Abstract:
Statins,the inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA)reductase,are mostly prescribed for the treatment of hyperlipidemia and prevention of cardiovascular events. Several studies have suggested that statins can reduce the risk of colorectal cancer,however,there is still a debate on its chemopreventive effect. This article summarized the local and overseas studies focusing on this issue,and made a brief overview on the effect of statins in prevention of colorectal cancer and adenoma and its potential mechanisms.
