A Randomized Controlled Study on Efficacy of Perioperative Administration of Houpupaiqi Mixture on Fast Track Surgery in Patients With Laparoscopic Colorectal Cancer
10.3969/j.issn.1008-7125.2018.03.005
- VernacularTitle:围手术期厚朴排气合剂在腹腔镜结直肠癌快速康复中疗效的随机对照研究
- Author:
Yier QIU
1
;
Yang LUO
;
Shaolan QIN
;
Ran CUI
;
Jun QIN
;
Jianjun CHEN
;
Minhao YU
;
Ming ZHONG
Author Information
1. 上海交通大学医学院附属仁济医院胃肠外科 200127
- Keywords:
Houpupaiqi Mixture;
Laparoscopes;
Colorectal Neoplasms;
Gastrointestinal Function;
Fast Track Surgery;
Therapy
- From:
Chinese Journal of Gastroenterology
2018;23(3):148-151
- CountryChina
- Language:Chinese
-
Abstract:
Background:Studies have shown that Houpupaiqi mixture is beneficial to the recovery of postoperative gastrointestinal function in patients undergoing open gastrointestinal surgery. However,there is no randomized controlled trial focusing on the efficacy of Houpupaiqi mixture on laparoscopic colorectal cancer patients. Aims:To investigate the efficacy of perioperative administration of Houpupaiqi mixture on fast track surgery in patients with laparoscopic colorectal cancer. Methods:A total of 170 colorectal cancer patients at Renji Hospital from January 2016 to February 2017 were enrolled into the prospective randomized double-blind controlled clinical trial. The patients were randomly divided into experimental group and control group,and Houpupaiqi mixture(50 mL)or placebo(50 mL)were administered 6 hours before surgery, as well as 6 and 12 hours after surgery,respectively. The clinical efficacy and safety were compared between the two groups. Results:The patients in experimental and control groups were well balanced with respect to the baseline characteristics. Compared with the control group,time to first anal exhaust,time to recovery of regular bowel sounds and time of postoperative hospital stay were significantly decreased in experimental group(P<0.05). However,no significant differences were observed in first time to defecation,first time to drink,first time to eat fluid diet and first time to eat solid food between the two groups(P>0.05). One patient with anastomotic fistula was found in each group. Conclusions:Houpupaiqi mixture significantly promotes the recovery of gastrointestinal function of patients undergoing laparoscopic colorectal cancer surgery,with reduction of time to recovery of regular bowel sounds,time to first anal exhaust,and shortening the postoperative hospital stay,which is in favor of rapid rehabilitation.
