Correlation of Family History of Gastric Cancer With Helicobacter pylori Infection and Pathological Changes of Gastric Mucosa in Patients With Chronic Gastritis
10.3969/j.issn.1008-7125.2018.01.010
- VernacularTitle:胃癌家族史与慢性胃炎幽门螺杆菌感染和胃黏膜病理变化的关系
- Author:
Tingting ZHU
1
;
Rongqiu ZHANG
;
Yingchun DOU
;
Changhong ZHOU
Author Information
1. 青岛大学附属青岛市市立医院东院干部保健科 266071
- Keywords:
Stomach Neoplasms;
Family History;
Helicobacter pylori;
Gastric Mucosa;
Inflammation;
Atrophy;
Metaplasia
- From:
Chinese Journal of Gastroenterology
2018;23(1):42-44
- CountryChina
- Language:Chinese
-
Abstract:
Background:Family history of gastric cancer is an important indicator of genetic susceptibility.Studies have shown that the family history of gastric cancer might have impact on Helicobacter pylori (Hp) infection and clinicopathological manifestations in patients with chronic gastritis.Aims:To investigate the correlation of family history of gastric cancer with Hp infection and pathological changes of gastric mucosa in patients with chronic gastritis.Methods:A total of 312 patients with chronic gastritis were enrolled to study the relationship between family history of gastric cancer and Hp infection,degree of gastric mucosal inflammation,activity of inflammation,and degree of atrophy and intestinal metaplasia.Results:In the 312 patients with chronic gastritis,165 (52.9％) had family history of gastric cancer,and 147 (47.1％) without family history of gastric cancer.Incidence of Hp infection,degree of gastric mucosal atrophy and intestinal metaplasia in patients with family history of gastric cancer were significantly higher than those without (P ＜ 0.05),but no significant differences in degree and activity of inflammation were found between the two groups (P ＞ 0.05).Conclusions:The incidence of Hp infection is higher in chronic gastritis patients with family history of gastric cancer.Family history of gastric cancer may aggravate gastric mucosal atrophy and intestinal metaplasia.
