Effects of Salicylate Administration on Metabolic Activity in the Rat Auditory Center
10.3969/j.issn.1006-7299.2018.01.019
- VernacularTitle:水杨酸盐对大鼠听觉中枢代谢功能影响的研究
- Author:
Bin YI
1
,
2
,
3
;
Weiqi BAO
;
Runjie SHI
;
Chuantao ZUO
;
Cong WU
;
Zhiwu HUANG
;
Hao WU
Author Information
1. 上海交通大学医学院附属第九人民医院耳鼻咽喉-头颈外科 上海 200011
2. 上海交通大学医学院耳科学研究所
3. 上海市耳鼻疾病转化医学重点实验室
- Keywords:
Tinnitus;
Salicylate;
Auditory center;
MicroPET;
Neuroplasticity
- From:
Journal of Audiology and Speech Pathology
2018;26(1):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the neural activity in the central auditory pathway by using a tinnitus an-imal model .Methods Twenty -four rats were randomly divided into the control ,acute salicylate treatment ,chronic salicylate treatment ,and recovery groups .The gap prepulse inhibition of acoustic startle test was used to confirm tinnitus -like behavior .After delivery of an intravenous bolus of fluorine -18 fluorodeoxyglucose (18F -FDG ) , small animal positron emission tomography scans were performed on rats .Results Only rats in chronic salicylate -treatment group showed evidence of experiencing tinnitus .The SUV ratios of the AC were significantly greater in the acute salicylate treatment group than in the control group (P<0 .01) ,suggesting relatively increased metabolism in the two brain regions of the rats in this group .The SUV ratios of the IC and AC (P<0 .01) ,but not of the CRB (P>0 .05) were greater in the chronic salicylate treatment group than in the control groups .There was a significant difference in whole brain SUVs between the control and acute salicylate treatment groups (P<0 .01) ,the whole brain SUVs in chronic salicylate treatment group were a little higher but showed no significant difference (P>0 .05) .There was no significant difference in the SUVs between the control and recovery groups (P>0 .05) .Conclu-sion These findings indicate that long -term salicylate administration induced tinnitus in rats and may have en-hanced neural activity corresponded to the up -regulated metabolic rate in our study .Alterations to neuroplasticity of the CNS may lead to tinnitus .
