The role of sex hormones on ion channels of drug-induced long QT syndromes
10.11958/20171441
- VernacularTitle:性激素对药物诱发的长QT综合征离子通道的作用
- Author:
Cui-Hua WANG
1
;
Xin-Le JIA
;
Yan-Gong LIU
;
Ming-Qi ZHENG
Author Information
1. 河北医科大学第一医院心脏中心 050031
- Keywords:
gonadal steroid hormones;
arrhythmias,cardiac;
sex factors;
myocardial repolarization;
review
- From:
Tianjin Medical Journal
2018;46(6):665-669
- CountryChina
- Language:Chinese
-
Abstract:
Female gender is an independent risk factor for the development of torsade de pointes (TdP) arrhythmias not only in congenital long QT syndromes(LQTs)but also in acquired long QT syndromes. Clinical evidences imply that sex steroid hormones appear to play important roles in gender differences by affecting the cardiac repolarization process of action potential. This review summarizes the effects of sex hormones on cardiac ion channel currents and the effects of gender differences on drug-induced long QT syndromes, and reveals the mechanism of sex hormone induced arrhythmia by computer simulation
