Research progress of STIM1 in tumor development and clinical application

VernacularTitle:基质相互作用蛋白分子1在肿瘤发生发展和临床应用中的研究进展
Author: Jin-Meng HU ¹ ; Jian WANG
Author Information

1. 天津医科大学肿瘤医院
Keywords: stromal interaction molecule1; calcium; store-operated calcium channels; store-operated calcium entry; Calcium release-activated calcium channels; Orai
From: Tianjin Medical Journal 2018;46(6):657-660
CountryChina
Language:Chinese
Abstract: Studies have shown that stromal interaction molecule 1(STIM1) is closely related to the development of tumors, and which is involved in the regulation of apoptosis, proliferation, migration and invasion in many human cancers. Blocking or knockdown of STIM1 can significantly inhibit the proliferation and migration of cancer cells. Elucidation of the regulatory mechanism of STIM1 in cancer cells will be helpful for the identification of new therapeutic targets. This paper reviews the mechanism of STIM1 molecule in different tumors and its clinical application.