Relationship between calcified aortic stenosis and peripheral blood inflammatory cells and lipids in the elderly
10.11958/20180410
- VernacularTitle:老年钙化性主动脉瓣狭窄与外周血炎性细胞及血脂水平的关系
- Author:
Yi-Peng TANG
1
;
Qing-Liang CHEN
;
Nan JIANG
;
Tong-Yun CHEN
;
Bo FU
;
Yun-Peng BAI
Author Information
1. 天津医科大学研究生院 300070
- Keywords:
aortic valve stenosis;
leukocytes;
aged;
calcific aortic stenosis;
inflammatory cells;
lipids
- From:
Tianjin Medical Journal
2018;46(5):466-470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between calcific aortic valve stenosis and inflammatory cells in peripheral blood and dyslipidemia in elderly patients(age ≥65 years).Methods A total of 76 elderly patients(≥65 years old)diagnosed as calcific aortic stenosis in our hospital from June 2015 to June 2017 were selected as the case group,and 78 seniors(excluding valvular heart disease)hospitalized due to chest discomfort were selected as the control group.The white blood cell count (WBC), neutrophil ratio (N%), neutrophil count (N), lymphocyte count (L), neutrophil lymphocyte ratio (NLR),hypersensitive C-reactive protein(hs-CRP),N-terminal B-type natriuretic peptide(NT-pro BNP),total cholesterol (TC),triglyceride(TG),apo-α,high-density lipoprotein(HDL),low-density lipoprotein(LDL),very low-density lipoprotein (VLDL)and other indicators were tested on admission.All these indicators were compared between the two groups. Results The levels of WBC, N%,N,NLR, hs-CRP, NT-pro BNP,VLDL were higher in the case group than those in the control group.The levels of L and HDL were significantly lower in the case group than those of the control group(P<0.05).Multiple regression analysis showed that smoking, the increased hs-CRP and NT-pro BNP levels were independent risk factors for senile calcific aortic stenosis.Conclusion Senile calcific aortic stenosis is not a simple degenerative disease.It is closely related to systemic inflammatory response and abnormal lipid metabolism.
