Osteoprotegerin system and coronary atherosclerotic heart disease:an update
10.11958/20170949
- VernacularTitle:骨保护素系统与冠状动脉粥样硬化性心脏病的研究进展
- Author:
Jia-Yan XIN
1
;
Hong-Liang CONG
;
Fu-Mei ZHAO
;
Yan-Qiu SONG
Author Information
1. 天津医科大学研究生院
- Keywords:
coronary artery stenosis;
molecular mechanism;
review;
osteoprotegerin
- From:
Tianjin Medical Journal
2018;46(1):104-109
- CountryChina
- Language:Chinese
-
Abstract:
Osteoprotegerin (OPG), as a member of the tumor necrosis factor (TNF) superfamily, is a soluble secretary glycoprotein, which is accompanied with NF-κB receptor activator (RANK), NF-κB receptor activator ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to form osteoprotegerin system. A large number of clinical and experimental studies have confirmed that osteoprotegerin system participates in physiological processes such as endothelial function, inflammatory reaction, oxidative stress and apoptosis, which is expected to be a biomarker for the occurrence, development, severity and long-term prognosis of coronary heart disease. In this paper, we summarized the biological effects and mechanism of the osteoprotegerin system in the occurrence and development of coronary heart disease and its future clinical application.
