Effect of Fascin-1 on Invasion and Metastasis of Gastric Carcinoma
10.3870/j.issn.1672-0741.2018.02.020
- VernacularTitle:Fascin-1对胃癌侵袭与转移的影响
- Author:
Dandan CHEN
1
;
Peng LI
;
Liquan REN
Author Information
1. 武汉市第四医院华中科技大学同济医学院附属武汉普爱医院消化内科
- Keywords:
Fascin-1;
gastric carcinoma;
invasion;
metastasis
- From:Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2018;47(2):227-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Fascin-1 in gastric carcinoma and its association with clinicopatho-logical features. Methods A total of 98 gastric cancer specimens were collected from our hospital from August 2014 to De-cember 2016.The expression of Fascin-1 mRNA and protein was detected in gastric cancer cell lines(MKN28,MKN45 and AGS)and gastric cancer tissues by real-time PCR,Western blotting and immunohistochemistry,respectively.The relationship between Fascin-1 protein expression and clinicopathological features was analyzed. Results Fascin-1 was highly expressed at mRNA and protein levels in MKN28 and MKN45 gastric cancer cell lines,and it was weakly expressed in AGS cell line.The ex-pression of Fascin-1 mRNA was much higher in gastric cancer tissues than in adjacent tissues.The expression of Fascin-1 was correlated with invasive depth,lymph node metastasis,lymphatic invasion,tumor differentiation and TNM stage(all P<0.05). Conclusion Fascin-1 is overexpressed in gastric cancer tissues.It is associated with the progression,invasion and malignancy of gastric cancer.It is expected to become a molecular marker for the progression of gastric cancer.
