The structure and function of JMJD2B protein and its progress in the development of malignant tumor
10.11904/j.issn.1002-3070.2018.03.012
- VernacularTitle:JMJD2B蛋白结构功能及在恶性肿瘤发生发展中的研究进展
- Author:
Siyu HOU
1
Author Information
1. 哈尔滨医科大学附属肿瘤医院 哈尔滨 150081
- Keywords:
JMJD2B protein;
Structure and function;
Malignant tumor
- From:
Practical Oncology Journal
2018;32(3):250-253
- CountryChina
- Language:Chinese
-
Abstract:
The JMJD family is an important group of histone demethylase. JMJD2B belongs to one of its family members,and is a JMJD containing a JmjC domain. It mainly regulates chromatin structure,transcription and cell appearance. Recent studies from domestic and foreign have demonstrated that JMJD2B protein is high expressed in human malignant tumors,such as liver cancer,gas-tric cancer,breast cancer,kidney cancer,and skin cancer. Moreover,it also shows that JMJD2B is involved in the occurrence,develop-ment,migration,infiltration,and proliferation of malignant tumors.
