Research progress of relationship between capecitabine related gene polymorphisms and hand-foot syndrome
10.11904/j.issn.1002-3070.2018.02.012
- VernacularTitle:卡培他滨相关基因多态性与手足综合征关系的研究进展
- Author:
Xiang LI
1
;
Duo LIU
;
Dongyuan WU
;
Xiaofan FAN
;
Juan ZHANG
Author Information
1. 哈尔滨医科大学附属肿瘤医院
- Keywords:
Capecitabine;
Adverse effects;
Hand-foot syndrome;
Gene polymorphism
- From:
Practical Oncology Journal
2018;32(2):149-153
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,capecitabine is widely used in clinical practice.Hand-foot syndrome is a dose-limiting toxicity, often manifested as numbness in the hands and feet,sensation of dullness,tingling,skin swelling or erythema,scaling,blisters or seri-ous pain.Its occurrence has seriously affected the chemotherapy effect and daily life of patients.Genetic mutations of capecitabine met-abolic enzymes play an important role in the drug efficacy and side-effect.In particular,the relationship between gene polymorphisms of CDA,CES,TP,DPD,TYMS,MTHFR and hand-foot syndrome has been widely investigated and achieved by researchers.This arti-cle reviews the relationship between capecitabine metabolizing enzymes and hand-foot syndrome in order to provide a reference for i-dentifying the biological target of hand-foot syndrome caused by capecitabine chemotherapy.
