Research progress of autophagy-mediated regulation of tumor associated macrophages
10.11904/j.issn.1002-3070.2018.02.008
- VernacularTitle:自噬介导的肿瘤相关巨噬细胞调控机制的研究进展
- Author:
Pei ZHANG
1
;
Shoubo CAO
Author Information
1. 哈尔滨医科大学附属肿瘤医院内六科
- Keywords:
Autophagy;
Tumor associated macrophages;
Tumor microenvironment
- From:Practical Oncology Journal
2018;32(2):130-134
- CountryChina
- Language:Chinese
-
Abstract:
Tumor cells,and a variety of stromal cells,immune cells and cytokines constitute a complex tumor microenviron-ment.Among them,tumor-associated macrophages(TAMs)are one of the most important stromal cells in microenvironment and ac-tively participate in tumor growth,invasion and metastasis.Autophagic activity not only plays a key role in the cellular stress response and maintaining the stability of the internal environment,but it also is closely associated with tumor,involving in the generation and re-cruitment of TAMs precursor cells in the tumor microenvironment and the important regulatory steps of polarization of the precursor cells to TAMs.The study of autophagy-mediated control of TAMs is conducive to a more comprehensive understanding of the tumor micro-environment in the complex regulatory network system,and may open a new situation in cancer treatment.
