Research progress of PERK signaling pathway under endoplasmic reticulum stress in tumor
10.11904/j.issn.1002-3070.2018.01.007
- VernacularTitle:内质网应激PERK通路在肿瘤中的研究进展
- Author:
Zhongrui OUYANG
1
;
Shuang CHAI
;
Haiqi ZHAO
Author Information
1. 哈尔滨医科大学附属第一医院神经外科
- Keywords:
ERS;
UPR;
Tumor cells;
PERK signaling pathway
- From:Practical Oncology Journal
2018;32(1):38-41
- CountryChina
- Language:Chinese
-
Abstract:
During growth,invasion and metastasis,tumor cells undergo endoplasmic reticulum stress(ERS)under hypoxia,hy-poglycemia and other environmental stresses.In response to ERS,tumor cells induce unfolded protein response(UPR).PERK signa-ling pathway as a key pathway to activate UPR can promote survival,proliferation,invasion and protection of tumor cells by increasing tumor tolerance to adverse microenvironment,inducting angiogenesis,inducing autophagosome formation and activating apoptotic signal molecules.Tumor cells are induced apoptotic and autophagic death when UPR reaches a certain extent.
