Correlation between SRD5A2 gene polymorphisms and prostate cancer in the population of Yi nationality in Yunnan Province
10.3969/j.issn.1006-5725.2018.12.017
- VernacularTitle:云南省彝族人群SRD5A2基因多态性与前列腺癌的相关性
- Author:
Yuhui LUO
1
;
Kangjian LI
;
Runyun GUAN
;
Jihong SHEN
;
Xiaodong LIU
;
Hao LI
Author Information
1. 昆明医科大学第一附属医院
- Keywords:
prostate cancer;
testosterone 5-alpha-reductase Ⅱ;
polymorphism;
Yunnan Yi population
- From:
The Journal of Practical Medicine
2018;34(12):1990-1994
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of rs523349(V89L),rs9282858(A49T)and TA repeat polymorphisms in testosterone 5-alpha-reductase Ⅱ(SRD5A2) gene with prostate cancer(PCa) in the population of Yi nationality in Yunnan Province. Methods Sanger sequence detection technique was used to detect rs523349(V89L),rs9282858(A49T)and TA repeat polymorphisms of SRD5A2 gene in 122 subjects with confirmed PCa and 135 age-matched healthy controls in the Yunnan Yi population,then the association of these polymorphisms with prostate cancer was analyzed. Results The AA genotype of rs9282858 site in SRD5A2 gene was not found between the Pca patients and the healthy controls in the Yunnan Yi population. The genotypic and allelic frequency distributions of rs523349 and rs9282858 were not significantly varied between the Pca patients and the controls(P>0.05). But the genotypic and allelic frequency distributions of TA repeat site were significantly varied(P < 0.05). The genotype containing(TA)9 allele was more common in the Pca patients than the healthy controls(P=0.033). Compared with(TA)0 allele subjects,(TA)9 allele subjects had a higher PCa risk(OR=2.181, 95% CI :1.111~4.281,P=0.021). Conclusion The TA repeat polymorphisms of SRD5A2 gene was associated with PCa risk in the Yunnan Yi population,which could be used as a risk factor to screen the high-risk individuals.
