Correlation of serum Ghrelin levels with disease severity in patients with non-traumatic osteonecrosis of femoral head:A preliminary study
10.3969/j.issn.1006-5725.2018.12.014
- VernacularTitle:血清Ghrelin水平与非创伤性股骨头坏死严重程度的相关性
- Author:
Zheng MAO
1
;
Yongbin YUE
;
Lu LU
;
Jingjie CHEN
;
Dan LIU
;
Chang ZHAO
;
Gang LIU
Author Information
1. 南方医科大学第三附属医院康复医学科
- Keywords:
non-traumatic osteonecrosis of femoral head;
Ghrelin
- From:
The Journal of Practical Medicine
2018;34(12):1978-1981
- CountryChina
- Language:Chinese
-
Abstract:
Objective The scope of this study was aimed to explore the relationship between serum Ghrelin levels and disease severity in non-traumatic ONFH patients. Methods 84 non-traumatic ONFH patients and 84 healthy controls were enrolled for this study in our hospital. The radiographic progression was determined by FICAT grading system. The clinical severity was evaluated by visual analogue scale(VAS),Harris hip scores(HSS). The serum APN concentrations were examined by enzyme-linked immunosorbent assay(ELISA).Serum adiponectin and IL-33 levels were also examined. The relationship between serum Ghrelin levels and radiographic severity,clinical severity and biochemical indices were investigated. Results Serum Ghrelin levels were significantly lower in ONFH patients than in healthy controls. Serum Ghrelin levels were negatively correlated with FICAT grading system. In addition,Serum Ghrelin levels were also negatively related to VAS scores and positively associated with HSS scores ,Last ,Serum Ghrelin levels were positively with adiponectin levels and negatively correlated with IL-33 levels. Conclusion Serum Ghrelin levels in non-traumatic ONFH patients were negatively associated with the disease severity. Decreased serum Ghrelin levels may reflect disease severity of non-traumatic ONFH.
