Role of sodium oxalate in radiosensitivity of hypoxic NPC CNE2 cells
10.3969/j.issn.1006-5725.2018.12.004
- VernacularTitle:草氨酸钠抑制乏氧鼻咽癌细胞CNE2血管紧张素Ⅱ生成提高放射敏感性
- Author:
Tan CHENG
1
;
Jieling ZHENG
;
Ying LIU
;
Guozhu XIE
;
Yawei YUAN
Author Information
1. 南方医科大学南方医院放疗科
- Keywords:
nasopharyngeal carcinoma;
hypoxia;
sodium oxalate;
radiosensitivity
- From:
The Journal of Practical Medicine
2018;34(12):1934-1937
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of sodium oxamate on the radiaosensitivity of hypoxic nasopharyngeal carcinoma CNE2 cells. Methods The production of lactate and angiotensin Ⅱ in CNE2 with or without sodium oxamate treatment was detected by lactate assay kit and angiotensin Ⅱ ELISA kit. Cell growth of hypoxic CNE2 with or without sodium oxamate treatment was measured in vitro by MTT method. Radiosensitivity of hypoxic CNE2 with or without sodium oxamate treatment was tested by clone formation assay. Results Lactate and angiotensin Ⅱ production of CNE2 cells treated with sodium oxalate was inhibited. Sodium oxalate inhibited the proliferation of hypoxic CNE2 cells. The radiosensitivity of hypoxic CNE2 cells treated with sodium oxalate was largely improved. Conclusions Sodium oxalate inhibits the proliferation of CNE2 cells in hypoxic condition and significantly enhances the radiosensitivity of hypoxic CNE2 cells. The mechanism may be involved in its inhibiting of angiotensinⅡproduction.
