Correlation between multimodality MRI findings and molecular typing of breast cancer
10.3969/j.issn.1006-5725.2018.10.037
- VernacularTitle:乳腺癌多模态MRI成像与其分子分型的相关性
- Author:
Zhen-Ping WANG
1
;
Guanghong LIU
;
Yang CHEN
;
Shishi LUO
;
Jianjun LI
;
Yingman ZHAO
;
Guanqiao LI
;
Jimin CHEN
Author Information
1. 海南省人民医院放射科 海口 570311
- Keywords:
breast neoplasms;
magnetic resonance imaging;
diffusion weighted imaging;
molecular typing
- From:
The Journal of Practical Medicine
2018;34(10):1725-1729
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of multimodal MRI of breast cancer with different molecular subtypes and the correlation between each molecular type and MRI findings. Methods Multimodality MRI date of 87 patients with breast cancer confirmed by pathology were retrospectively analyzed. According to the expression of estrogen receptors(ER),progesterone receptors(PR)and human epidermal growth factor receptor-2 (HER-2),the tumors were classified into triple-negative breast cancer,HER-2 overexpression,Luminal A and Lu-minal B subtypes. The MRI features of breast cancers of different molecular subtypes were compared. Results Among the 87 cases of breast cancer,luminal type A accounted for 29.9%(26/87),luminal type B accounted for 36.8%(32/87),HER-2 type accounted for 19.5%(17/87),and triple-negative type accounted for 13.8%(12/87). The average ADC value is 0.97 × 10-3 mm2/s;those whose irregular or edge burr like mass were more often Lu-minal type MRI,triple-negative breast cancer showed the edge smooth,clear boundary,annular enhancement, more easily showed enhanced mode of TIC type Ⅲ. The mean ADC values of type Luminal and HER-2 over-expres-sion were lower than the mean ADC values of the triple-negative type. Conclusion The different molecular sub-types of breast cancer MRI morphologic and hemodynamic characteristics and the value of ADC has certain charac-teristics. The MRI features of breast cancer can be predicted to analyze the molecular typing,providing a reference for clinical treatment.
