The antioxidant effect of serum bilirubin in lung cancer

VernacularTitle:血清胆红素在肺癌患者中的抗氧化作用
Author: Lidong LIU ¹ ; Zixing MA ; Qiying LIN ; Chengzhi ZHOU
Author Information

1. 广州医科大学附属第一医院检验科广州 510120
Keywords: lung cancer; serum bilirubin; antioxidant; SOD; MDA
From: The Journal of Practical Medicine 2018;34(10):1716-1719,1724
CountryChina
Language:Chinese
Abstract: Objective To study the antioxidant effect of serum bilirubin,an endogenous antioxidants,in the patients with lung cancer. Methods A total of 402 patients with lung cancer(patient group)and 422 healthy individuals(control group)were enrolled in this study. The concentrations of total bilirubin(TBIL)and direct bili-rubin(DBIL)were measured using Diazonium Salts reagent on an automated chemistry analyzer(AU5821,Beck-man Coulter)and concentrations of indirect bilirubin(IBIL)were calculated based on concentrations of TBIL and DBIL. The total activity of SOD and MDA concentrations of 104 patients and 57 controls were measured using Xan-thine oxidase and TBA reagents respectively. All data were analyzed using SPSS 19.0 Software. Results Compared with the control group,the concentrations of TBIL,DBIL,IBIL and the activity of SOD in the patient group were decreased(P < 0.05)but the concentrations of MDA were increased. However,no tendency was found from T1 to T4(TNM)groups. Conclusion There is antioxidant dysfunction within patient with lung cancer and the serum bilirubin would be involved in this process.