Diagnostic value of soluble urokinase-type plasminogen activator receptor in artificial joint infection
10.3969/j.issn.1006-5725.2018.10.029
- VernacularTitle:可溶性尿激酶型纤溶酶原激活物受体对人工关节感染的诊断价值
- Author:
Jian LIU
1
;
Yong GAO
;
Hong LI
;
Bing FANG
Author Information
1. 江西萍乡市第二人民医院骨二科 江西萍乡 337000
- Keywords:
soluble urokinase plasminogen activation receptor;
periprosthetic joint infection;
diagnos-tic potential
- From:
The Journal of Practical Medicine
2018;34(10):1693-1697
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the possible application of suPAR in the early diagnosis of periprosthet-ic joint infection(PJI). Methods A total of 53 patients with PJI who underwent total arthroplasty were selected as the PJI group. According to ratio of 1:2 between hospital and community,60 people were selected as the control group. The level of suPAR,CRP,IL-1,IL-6,TNF-α and IL-12 were measured. ROC curves were drawn to calcu-late the AUCs of these indicators. Results The level of serum suPAR in PJI patients was(6.70 ± 0.24)ng/mL, which was significantly higher than that in the control group(1.76 ± 0.11)ng/mL,and the difference was statisti-cally significant(P < 0.05). The level of serum IL-12 in PJI patients was(41.99 ± 4.02)pg/mL,which was signifi-cantly higher than that in the control group(23.57 ± 3.16)pg/mL,and the difference was statistically significant (P < 0.05). There was a positive correlation between suPAR and CRP,IL-6,TNF-α and IL-12,and their correlation coefficientwere 0.752,0.769,0.842,0.760 and 0.767,respectively. In addition,the area under the ROC curve of PJI was 0.888,while the AUC of CRP and IL-6 were 0.763 and 0.833,respectively. Conclusion Serum suPAR has a high diagnostic potential in the diagnosis of PJI and can be used as a potential diagnostic marker for PJI.
