Analysis of hematological characteristics of patient with different genotypes in lightβ-thalassemia
10.3969/j.issn.1006-5725.2018.10.028
- VernacularTitle:不同基因型轻型β-地中海贫血患者血液学特征
- Author:
Yuanyuan PEI
1
;
Jian RAN
;
Xiaoyi CONG
;
Xuan SHANG
;
Fu XIONG
;
Li DU
;
Fengxiang WEI
Author Information
1. 广东省深圳市龙岗区妇幼保健院遗传实验室 广东深圳 518172
- Keywords:
light β- thalassaemia;
β0/βN;
β+/βN;
hematological screening
- From:
The Journal of Practical Medicine
2018;34(10):1691-1692,1697
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the hematological characteristics of patients with light β- thalassae-mia and rapidly identify different mutational genotypes. Methods RBC、Hb、MCV、MCH、MCHC、RDW-CV and HbA2 were studied in the 646 patients,the differences between β0/βN and β +/βN mutations were also compared. Results Most of them were microcytic hypochromic anemia. The most common genotype were β654/βN(33%)、β41-42/βN(32.5%)、β17/βN(14.4%)、β - 28/βN(10%)respectively,β0/βN were relatively higher. The differences in RBC、MCV、MCH、RDW-CV and HbA2 were significant between β0/βN and β +/βN. Compared with β +/βN patients,the MCV and MCH of β0/βN were significantly reduced,RDW-CV and HbA2 were significantly higher. Conclusion Light β- thalassaemia with different genotypes has its own unique hematological features and can be quickly and ef-fectively identified. Clinical efficiency can be improved through hematological analysis.
