A clinical trial to study the failure of treating initial Helicobacter pylori eradication with the doxycycline,amoxicillin and clavulanate potassium containing rescue quadruple regimen
10.3969/j.issn.1006-5725.2018.10.019
- VernacularTitle:含多西环素、阿莫西林克拉维酸钾四联补救方案治疗幽门螺杆菌初次根除失败的临床研究
- Author:
Liu LIU
1
;
He HUANG
;
Liuping JIA
;
Huangwei CHEN
;
Xiaoyan LIANG
;
Weijian LUN
;
Xiapeng LUO
Author Information
1. 南方医科大学附属南海医院消化内科 广东佛山 528200
- Keywords:
doxycycline;
amoxicillin/clavulanate;
helicobacter pylori;
rescue;
therapy
- From:
The Journal of Practical Medicine
2018;34(10):1655-1658
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the efficacy and safety of quadruple regimen containing doxycy-cline,amoxicillin and clavulanate potassium in the treatment of Helicobacter pylori(Hp)after the failed initial eradication. Methods A total of 136 patients who had a failed course of initial eradication therapy were randomly divided into four groups. The 46 patients in group A were given rabeprazole,colloidal bismuth tartrate,doxycy-cline,amoxicillin and clavulanate potassium for 14 days). The 45 cases in group B were treated with rabeprazole, colloidal bismuth tartrate,doxycycline,amoxicillin and clavulanate potassium for 10 days. The 45 cases in control group received rabeprazole,colloidal bismuth tartrate,levofloxacin,amoxicillin for 14 days. After 4 weeks of treat-ment,the 13C-urea breath test was performed. The Hp eradication rates,adverse reactions,treatment compliance and cost-effectiveness ratio of the three groups were evaluated. Results A total of 130 patients completed the study. The intention to treat(ITT)and Per-protocol(PP)analyses revealed that the eradication rates of the three groups were 71.74% and 76.74%(group A),71.11% and 72.72%(group B),51.11% and 53.49%(control group),respectively. The ITT and PP of group were significantly higher than those of control group(P < 0.05). But there was no significant difference between group B and control group(P > 0.05). The rates of adverse reac-tions in each group were not statistically significant(P > 0.05),and the patient compliance of three groups was more than 80%. The cost and cost-effectiveness ratio showed that group B < control group < group A. Conclu-sions The quadruple therapy containing doxycycline,amoxicillin and clavulanate potassium as a rescue regimen given for 14 days is safe,effective and with high patient compliance,which is of high clinical significance.
