Expression and clinical significance of ADAMTS5 in human gastric cancer

VernacularTitle:ADAMTS5表达状态与胃癌临床病理及预后的关系
Author: Jintuan HUANG ¹ ; Chun-Yu CHEN ; Senmao LI ; Hao CHEN ; Yi LIAO ; Feng LIN ; Zuli YANG
Author Information

1. 中山大学附属第六医院(广东省胃肠肛门医院)胃肠外科广州 510655
Keywords: ADAMTS5; gastric cancer; immunohistochemistry; prognosis
From: The Journal of Practical Medicine 2018;34(10):1640-1643
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression status of A Disintegrin and Metalloproteinase with Thrombospondin motifs 5(ADAMTS5 )and its clinical significance in primary human gastric cancer(GC). Meth-ods ADAMTS5 protein expression in 176 GC tissues and 24 adjacent normal tissues was detected by immunohisto-chemistry(IHC),and its correlation to clinicopathological features and prognosis in patients with gastric cancer was analyzed. Results ADAMTS5 expression was lower in GC tissues compared with adjacent normal tissues. Moreover,low expression of ADAMTS5 was associated with gender,histologic type,degree of differentiation,M stage,TNM stage and vascular invasion,which was also an independent indicator for poor prognosis for GC pa-tients. Conclusions ADAMTS5 expression was lower in GC tissues,which was associated with clinicopathological features and prognosis,suggesting a novel potential prognostic indicator and therapeutic target in GC.