Effects of the rheic acid on the expression of PPARγin diabetic rats′mesangial cells
10.3969/j.issn.1006-5725.2018.10.014
- VernacularTitle:大黄酸对高糖诱导的大鼠肾脏系膜细胞的PPARγ信号通路的调控
- Author:
Shufang DUAN
1
;
Jiang HU
Author Information
1. 浙江省中医药大学第二附属医院内分泌科 杭州 310005
- Keywords:
rhein;
mesangial cells of rats;
p-JNK;
PPARγ
- From:
The Journal of Practical Medicine
2018;34(10):1636-1639
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the Rhein acid′s effect on the rats′ mesangial cell(MsC)induced by high glucose(30 mmol/L),and to explore its mechanism for protection. Methods Using Rhein acid′s on MsC in-duced by high glucose. Cell survival rate was detected by Annexin V-FITC. BcL-2 and PPARγ level were deter-mined by RT-PCR. P-JNK and PPARγ level were determined by Western blot. Results Rhein acid could inhibit p-JNK,increase PPARγ′s expression in MsC induced by high glucose,and inhibit cell survival rate. Conclusion Rhein acid can alleviate inflammatory response of MsC induced by high glucose via regulating the expression of p-JNK and PPARγ,and improve islet cell function,as a result of protecting kidney function of DN.
