Association of XRCC1,P53 and COX-2 genetic polymorphisms with susceptibility of esophageal cancer in Hakka population
10.3969/j.issn.1006-5725.2018.09.014
- VernacularTitle:XRCC1、P53、COX-2基因多态性与客家人群食管癌易感性的关系
- Author:
Tao LI
1
;
Chunfeng LAI
;
Minli ZHENG
;
Yuhui YANG
;
Bo QIU
Author Information
1. 嘉应学院医学院病理学教研室 广东梅州 514031
- Keywords:
XRCC1;
P53;
COX-2;
Hakka population;
esophageal cancer;
genetic polymorphisms
- From:
The Journal of Practical Medicine
2018;34(9):1463-1467
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of genetic factors in development of esophageal cancer by studying the association of XRCC1,P53 and COX-2 genetic polymorphisms with susceptibility of esophageal cancer in Hakka population. Methods A case-control study was performed with molecular epidemiological methods. A total of 122 patients with esophageal cancer(esophageal cancer group)and 123 healthy people(control group) were randomly selected from Hakka people in Meizhou area. The genotypes and alleles of XRCC1 rs25487,P53 rs1042522,and COX-2 rs689466 in both groups were detected,and the distribution characteristics were analyzed. Results The polymorphisms of XRCC1 rs25487(A/G),P53 rs1042522(C/G)and COX-2 rs689466(A/G)were found in Hakkan people in Meizhou area ,but there were no significant differences in the genotype and allele fre-quencies between the two groups. And after such as sex,age,stratified analysis showed also no significant results. Conclusions The study shows that the genetic polymorphisms of XRCC1 gene rs25487,P53 gene rs1042522 and COX-2 gene rs689466 are possibly not related with the susceptibility of esophageal cancer in Hakka population in Meizhou area.
