Clinical study of refined mirabilite vs. Chaishao Chengqi Decoction in treating sever acute pancreatitis complicated with abdominal compartment syndrome
10.3969/j.issn.1006-5725.2018.08.038
- VernacularTitle:精制芒硝与柴芍承气汤辅助治疗重度急性胰腺炎并腹腔间隔室综合征
- Author:
Xujuan LUO
1
;
Yan PENG
;
Lei SHI
;
Xia CHEN
Author Information
1. 西南医科大学附属医院消化内科 四川泸州646000
- Keywords:
sever acute pancreatitis;
abdominal compartment syndrome;
refined mirabilite
- From:
The Journal of Practical Medicine
2018;34(8):1376-1379
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy of refined mirabilite vs.Chaishao Chengqi Decoc-tion in treating sever acute pancreatitis(SAP) complicated with abdominal compartment syndrome(ACS). Methods 60 cases of SAP complicated with ACS were divided into treatment group(n = 32) and control group (n=28) with random number table.The treatment group was given the nasal feeding and enema with refined mira-bilite base on routine western medicine treatment. The control group was given the nasal feeding and enema with Chaishao Chengqi Decoction. The 2 groups were compared with respect to the changes of the APACHEⅡ scores, intra-abdominal pressure,endotoxin,calcitonin(PCT),tumor necrosis factor alpha(TNF-α),recovery time of bowel sound,self-defecation recovery time,length of stay and hospitalization expenses. Results After 7 days of treatment,the intestinal permeability index(endotoxin) and the related indicators(PCT,TNF-α) were significantly lower than before treatment in both groups(P<0.05).The abdominal pressure of both groups at days 1,3 and 7 days after treatment was significantly lower than before treatment(P < 0.05) but the difference between the two groups had no statistical significance(P > 0.05). In the 3rd and 7th days of the treatment,APACHEⅡ scores were significantly lower than before treatment(P<0.05),but the difference between the two groups was not statis-tically significant in the score(P>0.05).The two groups showed no significant difference in the recovery time of bowel sound,self-defecation recovery time,length of stay and hospitalization expenses(P > 0.05). Conclusions Refined mirabilite as adjuvant therapy in SAP with ACS,can effectively reduce the internal pressure,promote the intestinal function recovery,protect the intestinal mucosal barrier function,reduce intestinal bacteria and endotox-in translocation and the complications of infection.It has a similar clinical effect as Chaishao Chengqi Decoction to the recovery of the disease.
