Research on white matter lesion and behavioral and psychological symptoms of patients with Alzheimer's disease
10.3969/j.issn.1006-5725.2018.08.018
- VernacularTitle:阿尔茨海默病患者脑白质病变与精神行为症状的研究
- Author:
Nan MU
1
;
Jiyang PAN
;
Huawang WU
;
Canfang ZOU
;
Wentao LIU
;
Ping MA
Author Information
1. 广州市惠爱医院 广州510370
- Keywords:
Alzheimer's disease;
behavioral symptoms;
dementia;
White Matter Lesion
- From:
The Journal of Practical Medicine
2018;34(8):1297-1300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the difference in behavioral and psychological symptoms among Al-zheimer's disease(AD)patients with different severity of white matter hyperintensity(WMH). Methods A total of 37 AD patients were enrolled and were followed-up for 4 weeks. They were checked by 3.0 T MRI at baseline, including T1,T2-weighted phase and fluid-attenuated inversion recovery sequence(FLAIR phase).The image pro-fessionals analyzed the images and process data.The Fazekas scale was used for WMH rating.Assessment tools in-cluded the Neuropsychiatric Inventory(NPI)、MMSE and ADAS-cog. Results There were 14 patients in none-mild WMH group and 23 patients in moderate-severe WMH group. The age of two groups were 71.3 ± 12.5 and 78.7 ± 6.1 years old respectively(P<0.05).The comparison of NPI,MMSE and ADAS-cog assessment results be-tween two groups show that there is significance difference in NPI baseline scoring and 4-week scoring.The score in moderate-severe group w is higher than that in the none-mild group(P < 0.05). However,the changed value of baseline-4-week NPI is not statistically significant. There is no significant difference between MMSE and ADAS -cog score and changed value.Conclusion Taken together,the severity of WMH may be related to behavioral and psychological symptoms of patients with Alzheimer's disease.
