The value of HDL particles,the concordance of HDL-C and apoA-Ⅰ in assessing the severity of coronary artery disease
10.3969/j.issn.1006-5725.2018.08.011
- VernacularTitle:HDL颗粒、HDL-C与apoA-Ⅰ一致性评估冠心病严重程度的价值
- Author:
Yaling LIANG
1
;
Kai GUO
;
Lu HU
;
Yusheng MA
;
Jiahuan RAO
;
Jieni LONG
;
Zhigang GUO
Author Information
1. 南方医科大学南方医院惠侨医疗中心心血管病区 广州510515
- Keywords:
CAD;
HDL-C;
apoA-Ⅰ;
HDL particles;
concordance
- From:
The Journal of Practical Medicine
2018;34(8):1267-1272,1277
- CountryChina
- Language:Chinese
-
Abstract:
Objective The study was to analyze the relationship between HDL particles,the level of HDL-C and the concordance of HDL-C and apoA-Ⅰand the degree of coronary stenosis,then to explore their values in predicting coronary artery disease.Methods 591 patients were collected for coronary angiography,and calculated Gensini score respectively.HDL particles and the level of HDL-C,apoA-Ⅰwere analyzed in coronary artery disease (CAD)group and non-CAD group,stable angina pectoris(SAP)group and acute coronary syndrome(ACS)group and four groups divided by quartile of Gensini score(A,B,C,D).To investigate the relationship between the con-cordance of HDL-C and apoA-Ⅰand the severity of coronary artery disease,HDL-C,apoA-Ⅰwere divided into low and high group according to the 50 percentile,then pair wise combination was done into four groups. Results Compared with non-CAD group,HDL particles,the level of HDL-C,apoA-Ⅰwere significantly reduced in CAD group(P<0.001).Compared with SAP group,similar results were found in ACS group.HDL particles,the level of HDL-C,apoA-Ⅰwere decreased gradually in A,B,C,D group(P<0.001).The concordance of HDL-C and apoA-Ⅰwas related to the risk of CAD(P<0.001).The area under curve(AUC)of HDL particles was higher than that of HDL-C,the concordance of HDL-C and apoA-Ⅰ.Conclusions HDL particles,HDL-C,the concordance of HDL-C and apoA-Ⅰwere related to coronary stenosis.The value of HDL particles in predicting CAD risk was su-perior to that of HDL-C,the concordance of HDL-C and apoA-Ⅰ.
