An in vitro activity study of titanium surface modified by cluster-like anatase/rutile nanowires
10.3969/j.issn.1006-5725.2018.08.007
- VernacularTitle:簇状锐钛矿/金红石纳米线修饰纯钛表面的体外活性研究
- Author:
Yan GAO
1
;
Ying LIU
;
Shulan XU
;
Lei ZHOU
Author Information
1. 南方医科大学口腔医院 广东省口腔医院种植中心 广州510280
- Keywords:
nanowires;
titanium oxide;
biomaterials;
cell response
- From:
The Journal of Practical Medicine
2018;34(8):1248-1252
- CountryChina
- Language:Chinese
-
Abstract:
Objective Exploration of the titanium surface nano structure on the cellular bioactivity is of great significance to modifying the pure titanium surface. The unique cluster-like anatase/rutile nanowires (AR@NWs)was prepared and we further examined whether this surface was beneficial for early biological reaction in osteoblast.Methods Unique cluster-like anatase/rutile NWs(AR@NWs)was generated by using a simple hy-drothermal reaction via a three-step synthesis process.The crystal structure of nanowires on titanium surface was de-tected by X-ray diffractometer. The biological activity of nanowires was studied using in vitro cellular experiments. Results The AR@NWs was with a diameter of 200 nm. Three different types of NWs were generated during the production process,displaying different crystal structure and biological characteristics but similar surface topogra-phy and wettability.Compared with sodium titanate NWs(STi@NWs)and H2Ti2O5nanowires(HTi@NWs),AR@NWs surface was conductive to cell attachment. The data indicated that the surface titanium chemical composi-tion and crystal structure played an important role in the cell early response.To some extent,the generation of ana-tase and rutile compensated the cell-repelling properties of NWs. Conclusion Not only the surface physical prop-erties such as surface topography but also the surface chemistry plays an important role in promoting the cell early bioactivity.
