Mechanism study of the effect of ultrasound debridement combined with vacuum sealing drainage on dia-betic foot ulcer
10.3969/j.issn.1006-5725.2018.08.005
- VernacularTitle:超声清创刀联合负压创面系统治疗糖尿病足溃疡效果及其机制
- Author:
Fan YANG
1
;
Ning YANG
;
Tianping CHENG
;
Xiangyun LI
;
Jian ZHANG
;
Zhao WANG
;
Bo LIU
;
Wei ZHENG
;
Jin FENG
;
Hongqiang GUO
Author Information
1. 邢台市人民医院 河北邢台054000
- Keywords:
diabetic foot ulcer;
ultrasound debridement knife;
vacuum sealing drainage;
HIF-1α;
VEGF
- From:
The Journal of Practical Medicine
2018;34(8):1239-1243
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ultrasound debridement combined with vacuum sealing drainage on the treatment of diabetic foot ulcer and the potential mechanism. Methods Eighty-one patients with diabetic ulcer were randomly divided into two groups:ultrasound debridement combined with vacuum sealing drain-age as the experimental group,routine debridement combined with vacuum sealing drainage as the control group. The clinical curative effect,the reduction rate of the wound,the rate of blastocyst and the rate of bacterial clear-ance and blood flow were detected.Results The clinical curative effect in the experimental group was significantly better than that in the control group(P < 0.05). The rates of wound reduction and granulation were significantly higher than those in the control group(P<0.05).After 14-day treatment,the blood perfusion in the experimental group was significantly higher than that in the control group(P<0.05),and the expression of HIF-1α and VEGF in the ulcer tissue was significantly higher than that in the control group(P<0.05).Conclusions Ultrasound de-bridement combined with vacuum sealing drainage can improve the clinical efficacy,wound reduction rate,granu-lation coverage rate and bacterial clearance rate,and increase ulcer tissue blood flow. The potential mechanism is related with the increases of HIF-1α and VEGF in ulcer tissue.
