The correlation analysis among homocysteine,serum cystatin C and diabetic peripheral neuropathy
10.3969/j.issn.1006-5725.2018.08.002
- VernacularTitle:同型半胱氨酸及血清胱抑素C与糖尿病周围神经病变的相关性
- Author:
Mingyue JIN
1
;
Guojiao LI
;
Yan GUO
;
Yixuan LIU
;
Bingshu WU
;
Yanyan CHEN
;
Yingfang WANG
;
Difei WANG
Author Information
1. 中国医科大学附属第一医院老年内分泌科 沈阳110001
- Keywords:
type 2 diabetes;
diabetic peripheral neuropathy;
homocysteine;
serum cystatin C
- From:
The Journal of Practical Medicine
2018;34(8):1227-1230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations among homocysteine(Hcy)level,serum cystatin C (Cys-c)and diabetic peripheral neuropathy(DPN).Methods Two hundred and three diagnosed cases of type 2 diabetes were enrolled,including 123 DPN patients(DPN+)and 80 non-DPN(DPN-)patients.Levels of serum Hcy,Cys-c,high-sensitivity C-reactive protein(hs-CRP)and fiber fibrinogen(Fg)were detected.The above indi-cators and the baseline data such as sex,age,duration,BMI,WHR,HOMA-IR(CP),HOMA-islet(CP)were statistically analyzed. Results Hcy,Cys-c,and the duration of the DPN+ group were significantly higher than those in the DPN-group(P<0.05,respectively).HOMA-islet(CP)in the DPN-group was markedly higher than that in the DPN+group(P<0.01).The prevalence of DPN in the high level of Hcy group was much higher than that in the low and the normal level of Hcy group.Hcy was still significantly correlated with the Cys-c after taking the controlled procedure such as duration and fibrinogen. Conclusion High levels of Hcy and Cys-c are the criti-cal risk factors of DPN,collaborative determination of Hcy and Cys-c level might be of quitevaluable in early diag-nosis of DPN.
