Effects of individualized testosterone replacement therapy on serum total testosterone and sex hormone levels in male patients with late-onset hypogonadism
10.3969/j.issn.1006-5725.2018.06.032
- VernacularTitle:个体化睾酮替代疗法治疗男性迟发性性腺功能减退症患者对血清总睾酮和性激素水平的影响
- Author:
Qiang FENG
1
;
Mingxing QIU
Author Information
1. 四川省医学科学院
- Keywords:
individualized;
testosterone replacement therapy;
late-onset hypogonadism;
total testos-terone;
sex hormone
- From:
The Journal of Practical Medicine
2018;34(6):1003-1005,1009
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of individualized testosterone replacement therapy on serum total testosterone(TT)and sex hormone in males with late-onset hypogonadism(LOH). Methods A total of 78 cases with LOH males were divided into group A(TT<8 nmol/L)and group B(8≤TT<11.5 nmol/L)according to the serum TT level,and the B group was randomly divided into the B1 group and the B2 group.They were given the individualized testosterone replacement therapy,and the treatment effect was compared among the 3 groups. Results After treatment,the SHBG level in the 3 groups was significantly reduced(P<0.05)whereas the serum TT level was significantly higher(P<0.05). The TT level in the B1 group was significantly higher than that in the B2 group(P ＜0.05). The levels of E2and FSH in the 3 groups were significantly lower(P ＜0.05)whereas the level of P was significantly higher(P ＜0.05). The ADAM scores in the 3 groups were significantly better than those before treatment(P<0.05),and there was no significant difference between the B1 group and the B2 group (P ＞0.05). There was no significant difference in the total incidence rate of adverse reactions between the group A and the other two groups(P ＞0.05),and the rate in the B2 group was lower than that in the B1 group(P <0.05). Conclusions In supplementary treatment of LOH,TT ＜8 nmol/L recommended to choose conventional dose,and 8≤TT<11.5 nmol/L can choose a small dose of testosterone.
