Mechanism and clinical significance of TGF-β1 signal transduction pathway regulated by VEGF gene in nasopharyngeal carcinoma metastasis
10.3969/j.issn.1006-5725.2018.06.029
- VernacularTitle:VEGF基因调控TGF-β1信号转导通路在鼻咽癌转移中的机制及临床意义
- Author:
Zhong HUANG
1
;
Xunfan SHAO
;
Naiying ZHENG
Author Information
1. 广州医科大学附属肿瘤医院放疗科 广州510095
- Keywords:
vascular endothelial growth factor;
transformation growth factor-beta 1;
nasopharyngeal carci-noma
- From:
The Journal of Practical Medicine
2018;34(6):991-994
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the expression of VEGF and TGF-β1 in naso-pharyngeal carcinoma and the clinical characteristics and prognosis of nasopharyngeal carcinoma patients. Meth-ods The expression of VEGF and TGF-β1 in the local middle-late nasopharyngeal carcinoma tissue of 96 patients was detected using immunohistochemistry.The correlation and the prognosis analysis were analyzed in combination with their clinical characteristics and prognosis. Results Expression rate of VEGF was 66.7% and that of TGF-β 1 53.1%.The expression of VEGF and TGF-β1 were positively correlated in the advanced nasopharyngeal carcino-ma.Both VEGF and TGF-β1 had significant correlation with lymphatic metastasis.The effects of VEGF and TGF-β1 on MFS were analyzed by Cox single factor and the results showed that VEGF positive was an adverse prognostic factor(P<0.05).The effects of age,sex,lymphatic metastasis,local invasion,VEGF and TGF-β1 on MFS were analyzed with Cox multifactor analysis and the results showed that VEGF positive was an adverse prognostic factor (P < 0.01). Conclusion The detection of VEGF and TGF-β1 protein in nasopharyngeal carcinoma may help to predict the metastasis of nasopharyngeal carcinoma.
