Relationship between amniotic fluid erythropoietin and neonatal adverse outcome in fetal growth restric-tion pregnancy labored before 36 gestational week
10.3969/j.issn.1006-5725.2018.06.027
- VernacularTitle:36周前分娩的宫内生长受限孕妇羊水促红细胞生成素与新生儿不良结局的关系
- Author:
Xiaolan YUAN
1
;
Guocheng LIU
;
Li ZHANG
;
Yimin QI
;
Yaping HOU
;
Hongli DUAN
Author Information
1. 广东省妇幼保健院 广州511400
- Keywords:
fetal growth restriction;
erythropoietin;
amniotic fluid;
adverse neonatal outcome
- From:
The Journal of Practical Medicine
2018;34(6):982-986
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To assess the relationship between amniotic fluid erythropoietin(EPO)and neona-tal adverse outcome in fetal growth restriction(FGR)pregnancy labored during 28-36 gestational weeks.To explore the clinical application in timing of delivery. Methods The retrospective research had recruited 87 patients with single pregnancy complicated FGR,of which the gestational weeks range from 28 weeks to 36 weeks. All subjects were collected from amniotic fluid at cesarean section or within a week of cesarean section. Amniotic fluid EPO were detected according to the classical definition. We categorized EPO < 27 IU/L as an normal state,whereasE-PO≥27 IU/L as an abnormal state.The relationship between amniotic fluid EPO with biophysical profile,the flow velocity waveform/blood gas parameters of the umbilical artery,and the neonatal adverse outcome were observed. Results For FGR pregnant women who chose 28-36 weeks for delivery,the incidence of neonatal adverse out-comes was significantly higher in the amniotic fluid EPO increased group than that in normal concentration group (χ2= 9.49,P = 0.002). Pearson analysis showed that amniotic fluid EPO concentration was negatively correlated with umbilical artery pH(P<0.001,r=-0.908)and base excess(P<0.001,r=-0.624).However,it was pos-itively correlated with PCO2(P<0.001,r=0.631),whereas there was no significant correlation between amniotic fluid EPO concentration and PO2(P=0.068,r=-0.197).In addition,neither biophysical profile nor flow velocity waveform has difference in amniotic fluid EPO concentration. Conclusions The abnormal increased amniotic fluid EPO in FGR pregnant women who delivered before 36 gestational weeks were closely related to the adverse out-come of the newborn.The amniotic fluid EPO is expected to be an additional indicator of fetal hypoxia,which can help determine the time of birth.
