Risk factors of delayed bleeding after endoscopic submucosal dissection for early colorectal cancer and pre-cancerous lesions
10.3969/j.issn.1006-5725.2018.06.026
- VernacularTitle:内镜黏膜下剥离术治疗早期结直肠癌及癌前病变术后迟发性出血的危险因素分析
- Author:
Hongbo WANG
1
;
Miao LIU
;
Mingyao XU
;
Yin GUO
;
Xia PAN
;
Junjie HU
;
Qingbo CHEN
Author Information
1. 湖北省肿瘤医院内镜科 武汉430079
- Keywords:
early colorectal tumor;
precancerous lesions;
endoscopic submucosal dissection;
delayed bleeding
- From:
The Journal of Practical Medicine
2018;34(6):978-981,986
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investgate risk factors of delayed bleeding after endoscopic submucosal dissec-tion(ESD)for early colorectal tumor and precancerrous lesions. Methods We retrospectively reviewed clinical date of 138 patients with early colorectal tumor and precancerrous lesions who received ESD in Hubei Cancer Hos-pital from October 2012 to October 2016. Risk factors of delayed bleeding were analysed by univariate and multi-variable logistic regression analysis. Results Ten(7.2%)of 138 patients occurred delayed bleeding after ESD. Univariate analysis showed that there was significent difference between the bleeding group and the non-bleeding group in location of the lesion(P = 0.022),severe fibrosis of submucosa(P = 0.016),Obvious intraoperative bleeding(P = 0.032)and inadequate endosopic experience of endoscopist(P = 0.045). Multivariate Logistic re-gression analysis showed that location of lesion(P = 0.003,OR = 4.64,95%CI:1.71~12.58),severe fibrosis of submucosa(P = 0.009,OR = 4.83,95% CI:1.49~15.60)were independent risk factors of delayed bleeding after ESD for early colorectal tumor and precancerrous lesions. Conclusion Patients with early colorectal tumor and precancerrous lesions in the rectum and severe fibrosis of submucosa are prone to delayed bleeding after ESD.
