Clinical application of thyroid cancer gene detection in early diagnosis of thyroid nodules
10.3969/j.issn.1006-5725.2018.06.024
- VernacularTitle:甲状腺癌基因检测在甲状腺结节早期诊断中的临床应用
- Author:
Hongmei ZHANG
1
;
Hongyan ZHOU
;
Pei WANG
;
Foding YU
;
Juanjuan WANG
;
Lan YI
Author Information
1. 华中科技大学同济医学院附属武汉中心医院内分泌科 武汉430015
- Keywords:
[Key word] thyroid cancer(TC);
gene detection;
early diagnosis;
thyroid nodule
- From:
The Journal of Practical Medicine
2018;34(6):970-973
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical value of thyroid cancer gene detection and its joint diagnos-tic model in early diagnosis of thyroid nodule. Methods Retrospective study was used to analyze 61 cases of thy-roid nodules. These cases were divided into benign nodules and malignant nodules according to the pathology out-comes. We evaluated the AUC,sensitivity and specificity of preoperative fine needle aspiration biopsy(FNAB), thyroid cancer gene detection and color ultrasonography feature in the early diagnosis of thyroid nodule through lo-gistic regression analysis and ROC working curve. Results Among the 61 patients with thyroid nodules,there were 31 cases of benign thyroid nodules and 30 cases of malignant nodules.Diagnostic indexes significantly related with thyroid nodules and their AUC were listed as following:cancer gene detection 0.915(95% CI:0.814-0.971), FNAB 0.813(95% CI:0.691-0.902),low echo 0.657(95% CI:0.523-0.775),size of nodules 0.623(95% CI:0.488-0.745),joint diagnostic model respectively 0.957(95%CI:0.871-0.993). The value of joint diagnosis was the highest,whose sensitivity was 93.1% and the specificity was 90.3%.Conclusion Preoperative cancer gene de-tection joint FNAB and color ultra-sonography will improve the detection rate of thyroid cancer and reduce unneces-sary operation.
